According to the November 2014 University of Manitoba Newsletter current research at the University suggested that the vagus nerve may plan a role in Crohn's an inflammatory bowl disease. They reported that animal studies showed that the absence of the vagus nerve has a deleterious effect on the gut and conversely that stimulation of the vagus nerve centrally (brain stimulation) decreases the inflammatory effect on the gut. Note : There are 12 cranial nerves of which the vagus nerve is number 10.
It would seem that a retrospective study of those patients in the 1950-60 period that were diagnosed with peptic ulcer and who had the accepted surgical procedure for peptic (duodenal ) ulcers at the time, namely vagotomy and pyloroplasty might show a higher incidence of Chrohn's disease.
Incidentally the history of the treatment for pectic ulcer is a fascinating one. The surgical procedure was replaced by a medical treatment which could inhibit and/or reduce gastric juice production by the mucosal lining of the stomach without surgery. The final saga was an antibiotic treatment when researches from Australia (I believe ) showed that the aetiology was simply a bacterial infection belonging to the Mycobacterium app and found to be easily treatable by one of the common broad spectrum antibiotics.
I hope that the resolution of Crohn's does not have a similar saga to peptic ulcer and turn out to be nothing more than a bacterial and/or other microbial infection. The presence of inflammation would strongly suggest such aetiology.
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