Friday, November 7, 2014

Crohn's Disease and Vagotomy

According to the November 2014  University of Manitoba Newsletter current research at the University  suggested that the vagus nerve may plan a role in Crohn's an inflammatory bowl disease. They reported that animal studies showed  that the absence of the vagus nerve has a deleterious effect on the gut and conversely that stimulation of the vagus nerve centrally (brain stimulation) decreases the inflammatory effect on the gut. Note : There are 12 cranial nerves of which the vagus nerve is number 10.  
It would seem that a retrospective study of those patients in the 1950-60 period that were diagnosed with peptic ulcer and who had the accepted surgical procedure  for peptic (duodenal ) ulcers at the time, namely vagotomy and pyloroplasty might  show a higher incidence of Chrohn's disease.  
Incidentally the history of the treatment for pectic ulcer is a fascinating one.  The surgical procedure was replaced by a medical treatment which could inhibit and/or reduce gastric juice production by the mucosal lining of the stomach without surgery. The final saga was an antibiotic treatment when  researches from Australia (I believe ) showed that the aetiology was simply a bacterial infection belonging to the Mycobacterium app and found to be easily treatable by one of the common broad spectrum antibiotics.
I hope that the resolution of Crohn's does not have a similar saga to peptic ulcer and turn out to be nothing more than a bacterial and/or other microbial infection. The presence of inflammation would strongly suggest such aetiology.

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