Thursday, March 27, 2014

Why is the DHEA hormone- on the restricted list.

DHEA (Dehydroepiandrosterone) is a  hormone  naturally produced  in your bodies from cholesterol  under the influence of adrenocorticotrophic hormone from the pituitary gland. DHEA declines with age from its peak in the early 20's (over 3400 ng./ml. plasma  in males and 2200 ng in females). According to Dr. Roy L. Walford it declines by two thirds its value by the time we reach 70  Ref:The 120- year diet. Table 2.2 p54. Pub Simon and Schuster, Inc. New York.1986).
  DHEA is often referred to as the "parental" or "base" hormone since after being first converted  to the hormone androstenedione it is then further changed into the sex hormones testosterone and estrogens    http://www.webmd.com/vitamins-supplements/ingredientmono-331-DHEA.aspx?activeIngredientId=331&activeIngredientName=DHEA
 In the  link http://www.food.ca/content/view/702/302/  Dr. Michael Colgan and others discuss not only why the action that the Canadian Government has placed on DHEA by adding it to the restricted list but also the role DHEA plays  in preventing obesity  and muscle loss. He recommends that  the elderly should receive dietary supplements to achieve a plasma level equivalent to that of a 30 year old and strongly  urge the government to reconsider removing its band. I too also think its  unfortunate that the government has placed this drug on the restricted list. This restriction  discourages DHEA research  in the field of anti-aging ( Life Extension )specifically but also as a biological marker - a plasma test- for aging.
 I can't recall the exact reference but in the 1980-90s biogerontologists had found that  those patients who where near death from supposidly "natural causes" that their plasma DHEA levels were less than 500 ng/ml.  Considering DHEA's  important role in cell division (we produce over 300 billion new cells each day) it is tempting to postulate that these low levels may actually be the cause of death ! More importantly lets suppose that researchers designing life extension experiments  found that the  level of plasma DHEA remained high only in those octogenarians and other elderly whom they found  were  clinically  to be much younger than expected for their chronological age  (viz. from  biological markers tests of aging ,viz.  FeV1, Glucose tolerance, Creatine clearance,  etc.  Yes maybe plasma DHEA concentration tests could not only become a biological standard marker or test for aging that their life extension experiments are working. Could then be  on the verge for finding the fountain of youth?
I would strongly recommend that our governments review (and maybe also our scientists engaged in anti-aging or life extension research, read this somewhat provocative link  and reconsider removing DHEA from their restricted list. If they did maybe some of our  elderly might find that they not only loose that extra weight but may also find they can now return to playing tennis ,golf and other strenuous sports.

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